02 9231 0102
Park House Level 3, 187 Macquarie St Sydney NSW 2000

Fat Derived Stem Cell Injections

Stem cells are defined by two properties. Principally they can self-renew, that is they can divide and produce more stem cells of the same kind. Additionally, they can differentiate into specialised cells that carry out a specific function. There are many different types of stem cells. These include embryonic stem cells that are derived from the inner cell mass of early stage embryos, and various adult stem cells that are found in all tissues of the body. Embryonic stem cells possess the ability to differentiate into any cell type of the body, whereas adult stem cells are partially committed towards particular cell or tissue types.

Stem cell therapy uses stem cells, or their secretions, to replace or repair a patient’s cells or tissues that are damages, compromised or expired. The stem cell therapy might be delivered systematically via blood or transferred into the damaged tissue directly. Stem cells residing in one tissue can contribute to the repair of another due to their ability to modulate the immune response to injury and secrete growth factors.

As seen on Today Tonight - November 25, 2011

Arthritis Breakthrough - This world first sounds far-fetched & futuristic, but it's now reality. It’s the latest cutting edge treatment for Arthritis. Stem cells from fat are used to regenerate and heal arthritic joints.
  • What are MSC’s?
    Mesenchymal Stem Cells (MSCs) derive from connective tissue lineage, the mesenchyme, and are found in numerous connective tissues throughout the body. MSCs are normally obtained from one of three sources: adipose tissue, bone marrow and cord blood. Adipose tissue is highly vascularised enabling a high cell yield per gram of tissue compared with bone marrow.

    Other advantages in using adult adipose stem cells include:

    • Abundant supply of adipose tissue
    • 500-1000 times frequency of stem cells in fat than in bone marrow
    • No requirement to culture or manipulate stem cells
    • No need for general anaesthesia
    • Ability to obtain fat through minimally invasive procedures
    • Host compatible (autologous) transplants
    • No need for multiple injections given the high yields of cells from the one procedure
    • No ethical issues with embryos
  • Who can benefit from stem cells?
    We currently use the HiQCell system to obtain our MSCs. Thus far we have focussed on musculoskeletal conditions involving damaged joints, tendons and cartilage for treatment with stem cells.

    • On a study done by our clinic on the first 67 osteoarthritis patients treated with adipose-SVF and assessed each month for 6 months reported that over 80% of patients treated show a significant improvement of between 50 - 100% in pain and mobility of the joint.
    • On average, responders had a 60% decrease in pain scores in the first 2 weeks.
    • The repair process takes time - with the improvement at its maximum level by 6 months
    • Whether young or old the improvement by stem cell therapy was the same.
    • It is too early to determine the lifespan of the treatment as this treatment has only been available since 2009.


    Osteoarthritis (OA)


    Osteoarthritis (OA) is the most common joint disorder in the world. In Australia, 1 in 5 suffer from some form of osteoarthritis affecting almost 5 million people. The potential cost to the Australian economy is around 24 billion dollars. OA is a degenerative joint disease characterised by loss of articular cartilage in synovial joints. It can be defined by joint symptoms (pain and stiffness), by hyaluronic acidstructural pathology (x-rays and MRI) or by a combination of the two.

    Current treatments for OA aim at reducing symptoms of pain and stiffness. These can include: paracetamol, fish oils, glucosamine, NSAIDs, cortisone injections, hyaluronic acid. Non pharmaceutical treatments include weight loss, diet, physiotherapy and exercise. Joint replacement surgery has inherent risks, a significant recovery and rehab process and a finite life expectancy of 10-15 yrs.
    • Grade 2,3 and early 4 osteoarthritis
    • Mechanical impairment
    • Quality of life affected
    • Pain on most days
    — Osteoarthritis inclusion criteria
    We have used Stem cell treatments on the following conditions:

    • Knee osteoarthritis
    • Hip osteoarthritis
    • Shoulder osteoarthritis
    • Ankle osteoarthritis
    • Wrist osteoarthritis
    • Joints of the hands and feet osteoarthritis

    Tendinopathy


    • Rotator Cuff of the shoulder
    • Common extensors of the elbow (lateral epicondylitis) and flexors (medial epicondylitis)
    • Patellar tendon
    • Achilles tendon
    • Gluteus medius and minimus tendinosis of the hip
  • How do you minimise safety risks?
    During the harvesting procedure care is given to make sure that the chance of infection is minimised. Strict quality control measures, which include an intensive pre-operation scrubbing protocol and multiple bacteriological control processes to ensure the maximum level of safety is met for every procedure. Antibiotics are given before and after the procedure. Our samples are tested pre and post processing to ensure no bacteria contaminate the stem cells prior to insertion.

    While Celgen is a new technology, there are a number of similar procedures that have been in use for many years that are informative of the safety of adult stem cell procedures. Firstly, bone marrow transplants for reconstitution of the haemopoietic system have been in use in humans since the 1950’s. Secondly, fat derived from autologous liposuction has been transplanted for cosmetic and reconstructive purposes since the mid 1980’s.

    A meta-analysis of the literature on over 652 patients in 24 studies performed by Lalu et al (2010), assessed the safety of MSC administration by different routes. They concluded that MSC administration appears to be safe based upon the available evidence.

    The main liposuction risks are:

    • Infection and bruising at the site of fat removal
    • Allergic reaction to local anaesthetic or antibiotics
    • Delayed wound healing
    • Bleeding
    • Pain
    • Abdominal scarring

    The main risks of injection are:

    • Joint or soft tissue infection
    • Loss of skin pigmentation at the injection site
  • What is the procedure?
    The Celgen procedure involves injecting a mixture of regenerative stem cells taken from a person’s own fat tissue. The entire procedure takes no more than 3 hours to perform by a trained specialist medical doctor in a hospital. In most cases the procedure is done under light sedation and local anaesthetic, with no need to stay overnight.

    Preparation


    Patients are given a strict pre-op scrubbing kit to clean umbilicus and abdomen at home before surgery. On admission, the area may be shaved and further washed with surgical wash.

    Removal of adipose tissue


    2-3 small incisions are made in the abdomen and a fine cannula is used to infiltrate the area with saline solution and a local anaesthetic to prepare the fat. A small amount, 100-200g of fat, is then removed via suction aspiration from the lower abdomen.

    Isolation of Stem cells


    An experienced lab technician receives the aspirated fat cells immediately and sets about isolating the regenerative cells from the adipocytes. This involves isolating cells inside a laminar air flow safety cabinet. A series of washings and centrifugation is carried out to prepare a concentrate suspension for injection. Sterility, cell numbers and viability are taken before and after lab processing.

    Injection


    The injection site is selected and the area prepared for injection. Active stem cells are then injected into joints or tendons under ultrasound guidance. Patients are then free to be discharged. Often no pain is felt when walking out of the hospital.
    Sydney stem cell treatment
    Sydney stem cell therapy
    Sydney stem cell centre
  Park House Level 3
     187 Macquarie St
     Sydney NSW 2000
  (02) 9231 0102
  (02) 9231 0103
  info@sportsdoc.com.au
  (02) 9231 0102
  (02) 9231 0103
  info@sportsdoc.com.au